Colorectal Cancer

About Colorectal Cancer

Colorectal cancer is the 3rd most common cancer and one of the leading causes of death among cancer types. For patients whose cancer metastasized , the treatment options are chemotherapy, typically FOLFOX or FOLFIRI, and/or targeted therapy.

The mTOR oncogenic pathways (PI3K/AKT/mTOR) are frequently dysregulated in human cancers, including colorectal cancer [1]. Clinical studies demonstrated improved efficacy of mTOR inhibitors combined with the standard of care, in particular in patients with PTEN deficiency. [2]

AADi is conducting a study to evaluate the optimal dose and utility of ABI-009 combined with a standard of care, FOLXOX + bevacizumab, as first-line treatment in patients with metastatic colorectal cancer with and without PTEN deficiency (NCT03439462).

  1. Laes et al. Oncotarget 2017 8(48): 84426-84433.
  2. Gilcrease et al. Invest New Drug 2018 ahead of print.

Colorectal Cancer

March, 7 2019, Aadi Bioscience, Inc. (Aadi), For the first time in his life, Shanahan “Shanny” Dameral, 19, has a girlfriend. Soon, he’ll be graduating with a high school diploma and looking for his first job on the Kitsap Peninsula. What seems routine for many is a big deal for Dameral and other children living with treatment-resistant or intractable epilepsy. For reasons largely unknown, seizures in this subset of children persist long past their discovery in early childhood despite being treated with multiple medications and undergoing surgery to remove the affected parts of their brain. Diagnosed with epilepsy at age 5, life for Dameral has always come with seizures attached. When his seizures returned after a second brain surgery shortly after his 16th birthday, his mom Linley Allen, hoped for a medical breakthrough. “We needed to find something else since another surgery was out of the question,” Allen said. “We had heard about a drug being studied for a more severe seizure condition. I kept holding onto hope that it might be expanded to treat Shanny’s type of seizures because it was all we had at the time.”   See all and the original News article here: New Drug Trial Gives Hope for Treatment-Resistant Epilepsy