Soft Tissue Sarcomas

About Soft Tissue Sarcomas

Soft tissue sarcoma (STS) is a relatively rare and histologically diverse neoplasm of mesenchymal origin, occurring with an incidence of about 1% of all adult cancers, and includes >70 histologic subtypes. Treatment options for metastatic/relapsed STS are limited to anthracycline-based chemotherapy (eg, doxorubicin), administered alone or in combination with alkylating agents (eg, dacarbazine). However, drug resistance and toxicities often limit benefits of chemotherapy used to treat metastatic sarcomas. Aberrant signaling of the mammalian target of rapamycin (mTOR) pathway is common in sarcomas and other malignancies, and mTOR inhibitors have shown antitumor activity in sarcomas. [1]

Phase 1/2 studies are currently investigating in the safety and efficacy of ABI-009 in combination with nivolumab in patients with advanced undifferentiated pleomorphic sarcoma, liposarcoma, chondrosarcoma, osteosarcoma and Ewing’s sarcoma (NCT03190174) and in combination with pazopanib in patients with advanced nonadipocytic soft-tissue sarcomas (NCT03660930).

1. Chawla et al., J Clin Oncol 2012 30:78-84.

Soft Tissue Sarcomas

March, 7 2019, Aadi Bioscience, Inc. (Aadi), For the first time in his life, Shanahan “Shanny” Dameral, 19, has a girlfriend. Soon, he’ll be graduating with a high school diploma and looking for his first job on the Kitsap Peninsula. What seems routine for many is a big deal for Dameral and other children living with treatment-resistant or intractable epilepsy. For reasons largely unknown, seizures in this subset of children persist long past their discovery in early childhood despite being treated with multiple medications and undergoing surgery to remove the affected parts of their brain. Diagnosed with epilepsy at age 5, life for Dameral has always come with seizures attached. When his seizures returned after a second brain surgery shortly after his 16th birthday, his mom Linley Allen, hoped for a medical breakthrough. “We needed to find something else since another surgery was out of the question,” Allen said. “We had heard about a drug being studied for a more severe seizure condition. I kept holding onto hope that it might be expanded to treat Shanny’s type of seizures because it was all we had at the time.”   See all and the original News article here: New Drug Trial Gives Hope for Treatment-Resistant Epilepsy