Board

Neil Desai, PhD
Chairman of the Board and CEO

Neil is the Founder of Aadi Bioscience, Inc. He was former SVP, Global R&D, Abraxis Bioscience; VP, Strategic Platforms, Celgene Corp; Inventor of the nab® technology, Abraxane® and ABI-009. He successfully led the Abraxane team through all development stages. He has over 25 years of experience in novel therapeutic delivery systems with over 100 issued patents, over 40 peer-reviewed publications and book chapters, and over 200 presentations at scientific meetings. He is an active participant in FDA and EU Nanotechnology initiatives and a member of the Steering Committee for the National Cancer Institute (NCI) Alliance for Nanotechnology in Cancer. He holds board and advisory positions in various start-ups. He holds a M.S and Ph.D. in Chemical Engineering from the University of Texas at Austin, USA, and a B.S. in Chemical Engineering from the University Institute of Chemical Technology in Mumbai, India.

Carlo Montagner, Board Member
CEO Specialised Therapeutics, Australia

Carlo has extensive medical and pharmaceutical experience in the United States, Europe, China, Japan and Australia. Before forming Specialised Therapeutics, his roles included President of Abraxis Bioscience Inc; Global Head of Bayer-Schering Oncology; Global Team Leader of Sanofi-Aventis Oncology; Hospital Business Unit Head of Aventis Australia; and Director of the Hospital Business Unit at Rhone-Poulenc Rorer. Carlo holds a Masters of Science (Psychology) from RMIT University in Melbourne, Australia.

Richard Maroun, JD, Board Member

Richard Maroun is an executive partner at Frazier Healthcare Partners, a private equity and venture capital firm specializing in healthcare-focused investments. Before joining Frazier in 2015, Maroun was senior vice president and general counsel of Aptalis Pharmaceuticals from 2012 to 2014. He has also held numerous senior executive roles for APP Pharmaceuticals, Abraxis BioScience and American BioScience Inc. Mr. Maroun has worked with major financial organizations and independent law firms, and has held both legal and financial positions with companies including Merrill Lynch, Deloitte & Touche and McDonough, Holland & Allen. Mr. Maroun currently serves on the board of Leiter’s Enterprises, a private portfolio company of Frazier Healthcare Partners, and the Board of Trustees of John Carroll University. Mr. Maroun holds a J.D. from Santa Clara University Law School and a B.S. from John Carroll University.

Jerry Xiao, PhD, Board Member

Jerry is CEO of HermedCapital, which is a VC fund focusing on the healthcare industry investment. He is Ph.D. in Pharmacology, member of Bio China Advisor Committee, finished his Postdoctoral training in Rochester University, during which he co-founded a pharmaceutical company with Dr. Paul Okunieff, and won STTR support from US government. He was BD head of FosunPharma, the deputy chief of the IPO team for Fosun Pharma Listing in Hong Kong Exchange, the vice general manager of Fosun Pharmaceutical Technological Center, in charge of the evaluation of new technology, R&D and investment, he reviewed more than 150 projects per annum. He also served as a board member of FochonPharma (new drug development), Henlius (Biosimilar, antibody) and BeyondSpring (BYSI, Nasdaq), helping with the financing and technology transfer.

Mahendra Shah, PhD, Board Member

Dr. Shah is a venture partner at Vivo Ventures, a health-care focused venture capital firm. He is the founder and executive chairman of Semnur Pharmaceuticals. He was the founder, chairman, and CEO of NextWave pharmaceuticals, a pediatric focused specialty pharmaceutical company. Prior to founding NextWave Pharmaceuticals, Dr. Shah was the chairman and CEO of First Horizon Pharmaceuticals, which was sold to Shionogi Pharmaceuticals for $1.4B. Dr. Shah had also held various scientific and managerial roles in Fujisawa USA (Astellas), Schering-Plough and Bristol Myer-Squibb. Dr. Shah currently serves as chairman of the board of Essentialis Therapeutics, board member of Fortis Inc., Crinetic pharmaceuticals, and a member of the board of trustees of St. John’s University. He is also a board member and charter member of EPPIC and a charter member of TIE. Dr. Shah received his BS degree in Pharmacy from LM College of Pharmacy in Gujarat, India, and his PhD degree in Industrial Pharmacy from St Johns’s University.

Board

January, 3 2019, Aadi Bioscience, Inc. (Aadi), a clinical stage biopharmaceutical company focused on treating diseases driven by mTOR activation, today announced that its drug TARZIFYX™ (sirolimus albumin-bound nanoparticles for injectable suspension, ABI-009) has received Breakthrough Therapy Designation status from the FDA for the indication of Advanced (metastatic or locally advanced) Malignant PEComa (perivascular epithelioid cell tumor). The designation was granted based on data provided to the FDA from Aadi’s ongoing phase 2 registration trial (NCT02494570) in Advanced Malignant PEComa. In October 2018, Aadi also received Fast Track Designation from the FDA for TARZIFYX™ for the same indication. Aadi received orphan drug designation for TARZIFYX™ for the treatment of PEComa in December 2017. Aadi’s Phase 2 registration trial for Advanced Malignant Perivascular Epithelioid Cell Tumors (AMPECT), a rare form of sarcoma, has completed enrollment. Aadi previously received agreement from the FDA that this open label study in 30 efficacy evaluable patients with a primary endpoint of overall response rate could support the submission of an NDA for approval to treat this rare disease. mTOR inhibition is relevant in a number of disease states and has not been fully exploited in oncology, cardiovascular disease, CNS diseases, mitochondrial disease, diseases of ageing, etc. Due to the unique properties of Aadi’s drug including effective CNS penetration, it is being tested in nine ongoing clinical studies across these indications with encouraging results even outside of oncology in early studies in pulmonary hypertension and surgically refractory epilepsy. Aadi’s ongoing and planned clinical trials include Oncology (pediatric tumors, advanced sarcoma, first-line treatment of advanced colorectal cancer, newly diagnosed and recurrent glioblastoma, advanced neuroendocrine tumors), Cardiovascular indications (pulmonary arterial hypertension), CNS indications (surgically refractory epilepsy) and Mitochondrial disease (Leigh Syndrome). About Aadi and TARZIFYX™ (ABI-009) Aadi is a clinical stage biopharmaceutical company led by Dr. Neil Desai, an inventor of ABRAXANE®, TARZIFYX™ and the nab® technology platform. Aadi’s lead product TARZIFYX™ (sirolimus albumin-bound nanoparticles for injectable suspension, ABI-009) is an mTOR inhibitor complexed with human albumin that has significantly higher tumor accumulation and improved efficacy over other mTOR inhibitors in preclinical models. mTOR as a therapeutic target is well recognized in oncology, however Aadi aims to develop the full potential of albumin-bound sirolimus in therapeutic areas and diseases that are driven by mTOR activation and where the mTOR inhibitors have not or cannot be effectively exploited due to problems of pharmacology, effective drug delivery, safety or effective targeting to the disease site. These indications include oncology, cardiovascular, CNS, mitochondrial disease and diseases of ageing. About PEComa Perivascular epithelioid-cell tumors, defined by the World Health Organization as ‘mesenchymal tumors composed of distinctive cells that show a focal association with blood-vessel walls and usually express both melanocytic and smooth muscle markers,’ are a rare subset of soft-tissue tumors, with an undefined cell of origin. The PEComa family of tumors include lymphangioleiomyomatosis (LAM), angiomyolipoma (AML), clear-cell ‘sugar’ tumor of the lung (CCST), and a variety of morphologically and immunophenotypically similar tumors, which may arise in almost any body site (typically the uterus, retroperitoneum, genitourinary, and gastrointestinal tract), collectively termed PEComa-NOS. Malignant PEComas can have an aggressive clinical course including distant metastases and ultimate death. They have been shown to frequently harbor mutations in the TSC1 and/or TSC2 genes that result in the activation of mTORC1 pathway. Therefore, mTORC1 signaling is a promising therapeutic target for malignant PEComa, and anecdotal case reports have suggested clinical benefits of mTOR inhibitors in patients with malignant PEComas.   See original News Broadcast here: Businesswire.com/Aadi